A resorbable scaffold printed with 3D technology for trabecular bone replacement

Authors

  • Paola Andrea Bustamante Centro Atómico Ezeiza
  • Maria Carolina Anessi Centro Atómico Ezeiza

Abstract

Tissue engineering has become a discipline that must necessarily be investigated because the worldwide tissue demanding is not yet fulfill by the tissue banks. Our goal is to obtain a reabsorbable and not cytotoxic 3D scaffold that allows the generation of bone tissue. At first, we produce filaments of a biomaterial composed of polylactic acid (PLA) with different percentages of hydroxyapatite: 3, 5 and 10% w/w. These biomaterials were subjected to thermal, chemical and morphological tests. Then, using 3D technology, we print scaffolds that were treated with gamma radiation in a dose range of 15 kGy to 25 kGy, for sterilization purposes and to control the degradation rate of the composite. These scaffolds were subjected to biological and degradation tests whose results showed that these materials are non-cytotoxic (cell viability greater than 70%) and that they also have good cell adhesion. The result of the degradation test was not as expected; therefore we should continue working on that. In general, we can say that the developed biomaterial has the potential to be used as scaffolding for the replacement of trabecular bone tissue.

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Published

30/12/2020

Issue

Section

Scientific articles

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